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Study Information
Study Attribute Value
CEBS Accession Number: 002-02255-0001-0000-7
Chemical Name: Hexanamide
CASRN: 628-02-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 826805_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Test Failure 

Trial #: 1    Activation: No Activation    Date: 04/19/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 560 0.535 11.20 26.0 0.000
Test Chemical Hexanamide 
50         
 50 1042 553 0.531 11.06 26.0 -0.776 
167         
 50 1049 558 0.532 11.16 26.0 -0.547 
500         
 0 0 0 0.000 0.00 0.0 N/A 
1670         
 50 1050 690 0.657 13.80 26.0 22.862 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1050 915 0.871 18.30 26.0 62.926
Mitomycin-C 
 0.01      
 5 105 265 2.524 53.00 26.0 371.862
Trend: 4.035        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/22/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 445 0.424 8.90 26.0 0.000
Test Chemical Hexanamide 
2000         
 50 1047 541 0.517 10.82 33.5 21.921 
2500         
 50 1052 606 0.576 12.12 33.5 35.921 
3000         
 50 1050 568 0.541 11.36 33.5 27.640 
3500         
 0 0 0 0.000 0.00 33.5 N/A 
4000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1049 782 0.745 15.64 26.0 75.898
Mitomycin-C 
 0.01      
 5 105 271 2.581 54.20 26.0 508.989
Trend: 4.145        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/19/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 556 0.531 11.12 26.0 0.000
Test Chemical Hexanamide 
500         
 50 1050 540 0.514 10.80 26.0 -3.063 
1670         
 50 1050 607 0.578 12.14 26.0 8.965 
5000         
 50 1043 556 0.533 11.12 26.0 0.479
Positive Control Cyclophosphamide 
 0.4       
 50 1048 847 0.808 16.94 26.0 52.338
Cyclophosphamide 
2         
 5 104 204 1.962 40.80 26.0 269.729
Trend: 0.740        
Probability: 0.230        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/22/1984    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 499 0.476 9.98 26.0 0.000
Test Chemical Hexanamide 
7000         
 50 1046 489 0.467 9.78 26.0 -1.817 
8000         
 50 1050 525 0.500 10.50 26.0 5.010 
9000         
 50 1046 661 0.632 13.22 33.5 32.718 
10000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1051 749 0.713 14.98 26.0 49.672
Cyclophosphamide 
2         
 5 105 197 1.876 39.40 26.0 294.038
Trend: 4.995        
Probability: 0.000