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Study Information
Study Attribute Value
CEBS Accession Number: 002-02255-0002-0000-8
Chemical Name: Hexanamide
CASRN: 628-02-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 826805_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Test Failure 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 06/07/1984    Harvest Time: 22 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Hexanamide 
4000         
 100 5 0.050 5.0 2 0.020 2.0 2 0.020 2.0 1 0.010 1.0 
4500         
 100 7 0.070 6.0 1 0.010 1.0 6 0.060 5.0 0 0.000 0.0 
5000         
 100 11 0.110 10.0 0 0.000 0.0 11 0.110 10.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.025     
 100 15 0.150 14.0 6 0.060 6.0 7 0.070 7.0 2 0.020 2.0
Mitomycin-C 
 0.063     
 25 31 1.240 56.0 12 0.480 44.0 7 0.280 12.0 12 0.480 12.0
Trend: 2.390 -0.894 3.223  
Probability: 0.008 0.814 0.001  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/07/1984    Harvest Time: 10.8 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 0 0.000 0.0 2 0.020 2.0 2 0.020 2.0
Test Chemical: Hexanamide 
8000         
 100 35 0.350 28.0 11 0.110 11.0 24 0.240 21.0 0 0.000 0.0 
8500         
 100 59 0.590 40.0 18 0.180 15.0 41 0.410 31.0 0 0.000 0.0 
9000         
 25 22 0.880 80.0 2 0.080 4.0 20 0.800 76.0 0 0.000 0.0 
9500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 13 0.130 10.0 1 0.010 1.0 12 0.120 9.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 50 14 0.280 20.0 9 0.180 16.0 5 0.100 8.0 0 0.000 0.0
Trend: 8.006 2.722 7.790  
Probability: 0.000 0.003 0.000  


Trial #:2   Activation: No Activation    Date: 07/10/1984    Harvest Time: 22 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Hexanamide 
4500         
 100 12 0.120 9.0 2 0.020 2.0 9 0.090 7.0 1 0.010 1.0 
5000         
 100 6 0.060 4.0 1 0.010 1.0 4 0.040 3.0 1 0.010 1.0 
6000         
 100 7 0.070 7.0 2 0.020 2.0 4 0.040 4.0 1 0.010 1.0
Positive Control: Mitomycin-C 
 0.025     
 100 14 0.140 9.0 2 0.020 2.0 10 0.100 6.0 2 0.020 2.0
Mitomycin-C 
 0.063     
 50 25 0.500 34.0 10 0.200 16.0 15 0.300 24.0 0 0.000 0.0
Trend: 1.401 0.426 1.028  
Probability: 0.081 0.335 0.152