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Study Information
Study Attribute Value
CEBS Accession Number: 002-02267-0001-0000-0
Chemical Name: Hydrazobenzene
CASRN: 122-66-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 522990_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/16/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 444 0.425 8.88 26.0 0.000
Test Chemical Hydrazobenzene 
1.4       
 50 1046 478 0.457 9.56 26.0 7.555 
4.2       
 50 1048 471 0.449 9.42 26.0 5.777 
14         
 50 1046 507 0.485 10.14 26.0 14.080
Positive Control Mitomycin-C 
 0.005     
 25 524 572 1.092 22.88 26.0 156.920
Trend: 1.857        
Probability: 0.032        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/16/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 469 0.447 9.38 26.0 0.000
Test Chemical Hydrazobenzene 
1.4       
 50 1049 470 0.448 9.40 26.0 0.213 
4.2       
 50 1047 502 0.479 10.04 26.0 7.241 
14         
 50 1049 657 0.626 13.14 28.0 40.085
Positive Control Cyclophosphamide 
1         
 25 523 490 0.937 19.60 26.0 109.555
Trend: 5.873        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/31/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 515 0.491 10.30 26.0 0.000
Test Chemical Hydrazobenzene 
5         
 50 1050 737 0.702 14.74 26.0 42.834 
10         
 34 715 456 0.638 13.41 26.0 29.782 
15         
 25 517 402 0.778 16.08 28.0 58.230
Positive Control Cyclophosphamide 
1         
 50 1051 900 0.856 18.00 26.0 74.258
Trend: 5.978        
Probability: 0.000