Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02267-0002-0000-1 |
Chemical Name: | Hydrazobenzene |
CASRN: | 122-66-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 522990_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Questionable |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Hydrazobenzene | 4.2 | 100 | 8 | 0.080 | 7.0 | 0 | 0.000 | 0.0 | 8 | 0.080 | 7.0 | 0 | 0.000 | 0.0 |
14 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
42 | 100 | 11 | 0.110 | 10.0 | 3 | 0.030 | 3.0 | 8 | 0.080 | 7.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 100 | 21 | 0.210 | 17.0 | 4 | 0.040 | 4.0 | 17 | 0.170 | 15.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.15 | 100 | 24 | 0.240 | 22.0 | 9 | 0.090 | 8.0 | 15 | 0.150 | 14.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.801 | 1.322 | 1.332 | ||||||||||||
Probability: | 0.036 | 0.093 | 0.091 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Hydrazobenzene | 1.4 | 100 | 9 | 0.090 | 8.0 | 1 | 0.010 | 1.0 | 8 | 0.080 | 8.0 | 0 | 0.000 | 0.0 |
4.2 | 100 | 10 | 0.100 | 9.0 | 2 | 0.020 | 2.0 | 8 | 0.080 | 7.0 | 0 | 0.000 | 0.0 | ||
14 | 100 | 15 | 0.150 | 14.0 | 5 | 0.050 | 5.0 | 10 | 0.100 | 9.0 | 0 | 0.000 | 0.0 | ||
42 | 100 | 15 | 0.150 | 15.0 | 9 | 0.090 | 9.0 | 6 | 0.060 | 6.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 22 | 0.220 | 18.0 | 11 | 0.110 | 9.0 | 11 | 0.110 | 11.0 | 0 | 0.000 | 0.0 |
Trend: | 3.197 | 3.400 | 1.167 | ||||||||||||
Probability: | 0.001 | 0.000 | 0.122 |