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Study Information
Study Attribute Value
CEBS Accession Number: 002-02269-0002-0000-3
Chemical Name: Hydroquinone
CASRN: 123-31-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 886668_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 03/17/1982    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Hydroquinone 
5         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
7.5       
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
10         
 100 4 0.040 4.0 1 0.010 1.0 2 0.020 2.0 1 0.010 1.0 
15         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
20         
 50 5 0.100 8.0 2 0.040 4.0 3 0.060 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 50 10 0.200 20.0 4 0.080 8.0 6 0.120 12.0 0 0.000 0.0
Trend: 1.623 0.177 2.664  
Probability: 0.052 0.430 0.004  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/04/1982    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 0 0.000 0.0 2 0.020 2.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Hydroquinone 
150         
 100 5 0.050 4.0 4 0.040 3.0 1 0.010 1.0 0 0.000 0.0 
300         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
450         
 100 22 0.220 17.0 10 0.100 9.0 12 0.120 12.0 0 0.000 0.0 
600         
 100 29 0.290 19.0 9 0.090 8.0 7 0.070 7.0 13 0.130 4.0
Positive Control: Cyclophosphamide 
25         
 50 10 0.200 18.0 4 0.080 8.0 6 0.120 12.0 0 0.000 0.0
Trend: 5.157 2.913 3.848  
Probability: 0.000 0.002 0.000