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Study Information
Study Attribute Value
CEBS Accession Number: 002-02288-0001-0000-3
Chemical Name: Iodinated glycerol
CASRN: 5634-39-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 773890_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 08/31/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 370 0.353 7.40 25.8 0.000
Test Chemical Iodinated glycerol 
50         
 50 1047 701 0.670 14.02 25.8 89.640 
167         
 10 210 282 1.343 28.20 25.8 280.355 
500         
 5 105 220 2.095 44.00 25.8 493.462 
1670         
 0 0 0 0.000 0.00 25.8 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1044 627 0.601 12.54 25.8 70.109
Mitomycin-C 
 0.01      
 5 104 211 2.029 42.20 25.8 474.657
Trend: 24.211        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/31/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 485 0.463 9.70 25.8 0.000
Test Chemical Iodinated glycerol 
500         
 50 1049 497 0.474 9.94 25.8 2.279 
1670         
 50 1050 701 0.668 14.02 25.8 44.123 
5000         
 50 1047 902 0.862 18.04 25.8 85.979
Positive Control Cyclophosphamide 
 0.4       
 50 1046 657 0.628 13.14 25.8 35.593
Cyclophosphamide 
2         
 5 105 200 1.905 40.00 25.8 311.193
Trend: 12.781        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/29/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 25 525 184 0.350 7.36 25.5 0.000
Test Chemical Iodinated glycerol 
2500         
 25 525 310 0.590 12.40 25.5 68.478 
3750         
 25 525 462 0.880 18.48 25.5 151.087 
5000         
 25 524 488 0.931 19.52 25.5 165.724
Positive Control Cyclophosphamide 
 0.4       
 25 525 357 0.680 14.28 25.5 94.022
Cyclophosphamide 
2         
 5 105 232 2.210 46.40 25.5 530.435
Trend: 12.710        
Probability: 0.000