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Study Information
Study Attribute Value
CEBS Accession Number: 002-02288-0002-0000-4
Chemical Name: Iodinated glycerol
CASRN: 5634-39-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 773890_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 11/04/1987    Harvest Time: 10 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 200 5 0.025 2.0 0 0.000 0.0 5 0.025 2.0 0 0.000 0.0
Test Chemical: Iodinated glycerol 
1250         
 200 14 0.070 7.0 5 0.025 2.5 9 0.045 4.5 0 0.000 0.0 
1875         
 46 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
2500         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 200 29 0.145 11.5 14 0.070 6.5 15 0.075 6.0 0 0.000 0.0
Mitomycin-C 
 0.75      
 25 17 0.680 44.0 5 0.200 16.0 12 0.480 32.0 0 0.000 0.0
Trend: -1.805 -0.722 -1.660  
Probability: 0.964 0.765 0.952  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/04/1987    Harvest Time: 11.8 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Iodinated glycerol 
2500         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
3750         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
5000         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 27 0.135 10.5 5 0.025 2.5 22 0.110 8.5 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 17 0.680 48.0 5 0.200 20.0 12 0.480 40.0 0 0.000 0.0
Trend: 0.697 -1.355 1.812  
Probability: 0.243 0.912 0.035  


Trial #:2   Activation: No Activation    Date: 11/19/1987    Harvest Time: 10.3 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Medium 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Iodinated glycerol 
1250         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0 
1875         
 100 12 0.120 9.0 1 0.010 1.0 11 0.110 8.0 0 0.000 0.0 
2500         
 100 24 0.240 19.0 2 0.020 2.0 22 0.220 19.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 50 20 0.400 32.0 6 0.120 10.0 14 0.280 24.0 0 0.000 0.0
Mitomycin-C 
 0.75      
 25 15 0.600 32.0 8 0.320 24.0 7 0.280 16.0 0 0.000 0.0
Trend: 3.987 0.181 4.540  
Probability: 0.000 0.428 0.000