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Study Information
Study Attribute Value
CEBS Accession Number: 002-02288-0010-0000-3
Chemical Name: Iodinated glycerol
CASRN: 5634-39-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 616705
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 96 137 130 45 49
    99 86 143 48
    76 81 111 49
    85 95 136 54
Test Chemical Iodinated glycerol 
 0.125     
 90 95 120 44 54
    97# 94 148 51
    65 64 133 68
  
 0.25      
 51 58 126 82 83*
    37 41 118 106
    77 86 140 60
  
 0.375     
 76 61 210 92 85*
    79 77 199 84
    77 77 184 79
  
 0.5       
 87 67 275 106 109*
    75 56 290 129
    89 69 244 92
  
 0.75      
 67 59 316 158 210*
    60 58 376 208
    52 48 409 265
  
1         
 71 51 480 224 252*
    66 52 551 278
    78 46 597 255
Positive Control Methyl Methane Sulfonate 
5         
 74 50 671 304 349*
    67 45 628 312
    57 47 741 431

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 103 107 87 28 30
    121r 113 94 26
    104# 93 97 31
    142r 119 127 30
Test Chemical Iodinated glycerol 
 0.5       
 80 73 146 61 62*
    86 77 165 64
    73 66 135 62
  
 0.75      
 86 63 240 93 92*
    79# 65 203 86
    99# 64 290 98
  
1         
 78 48 371 160 134*
    77# 54 290 126
    81 58 279 116
  
1.5       
 70 41 451 215 232*
    67 45 499 249
    87# 48 609 233
  
2         
 82 35 738 300 272*
    95 41 789 276
    93 38 670 240
  
3         
 80 17 784 328 344*
    92 18 785 285
    64 12 798 418
Positive Control Methyl Methane Sulfonate 
5         
 68 44 582 286 285*
    78# 47 674 288
    68 59 574 280

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination