Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02288-0010-0000-3
Chemical Name:	Iodinated glycerol
CASRN:	5634-39-9
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	616705
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. uL/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	96	137	130	45	49
			99	86	143	48
			76	81	111	49
			85	95	136	54
Test Chemical	Iodinated glycerol	0.125	90	95	120	44	54
			97#	94	148	51
			65	64	133	68
		0.25	51	58	126	82	83*
			37	41	118	106
			77	86	140	60
		0.375	76	61	210	92	85*
			79	77	199	84
			77	77	184	79
		0.5	87	67	275	106	109*
			75	56	290	129
			89	69	244	92
		0.75	67	59	316	158	210*
			60	58	376	208
			52	48	409	265
		1	71	51	480	224	252*
			66	52	551	278
			78	46	597	255
Positive Control	Methyl Methane Sulfonate	5	74	50	671	304	349*
			67	45	628	312
			57	47	741	431

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. uL/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	103	107	87	28	30
			121r	113	94	26
			104#	93	97	31
			142r	119	127	30
Test Chemical	Iodinated glycerol	0.5	80	73	146	61	62*
			86	77	165	64
			73	66	135	62
		0.75	86	63	240	93	92*
			79#	65	203	86
			99#	64	290	98
		1	78	48	371	160	134*
			77#	54	290	126
			81	58	279	116
		1.5	70	41	451	215	232*
			67	45	499	249
			87#	48	609	233
		2	82	35	738	300	272*
			95	41	789	276
			93	38	670	240
		3	80	17	784	328	344*
			92	18	785	285
			64	12	798	418
Positive Control	Methyl Methane Sulfonate	5	68	44	582	286	285*
			78#	47	674	288
			68	59	574	280

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination