COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02292-0001-0000-8
Chemical Name: Iodoform
CASRN: 75-47-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 123235_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/20/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 426 0.407 8.52 26.0 0.000
Test Chemical Iodoform 
 0.5       
 50 1045 417 0.399 8.34 26.0 -2.019 
1.6       
 50 1045 436 0.417 8.72 26.0 2.445 
5         
 50 1047 429 0.410 8.58 26.0 0.608 
16         
 50 1046 488 0.467 9.76 26.0 14.554
Positive Control Mitomycin-C 
 0.005     
 50 1050 514 0.490 10.28 26.0 20.198
Trend: 2.041        
Probability: 0.021        

Trial #: 2    Activation: No Activation    Date: 08/24/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 409 0.389 8.18 26.0 0.000
Test Chemical Iodoform 
1.6       
 50 1049 470 0.448 9.40 26.0 15.243 
5         
 50 1051 467 0.444 9.34 26.0 14.290 
16         
 50 1048 489 0.467 9.78 26.0 20.016
Positive Control Mitomycin-C 
 0.005     
 25 526 610 1.160 24.40 26.0 198.289
Trend: 2.521        
Probability: 0.006        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/20/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 461 0.440 9.22 26.0 0.000
Test Chemical Iodoform 
5         
 50 1049 445 0.424 8.90 26.0 -3.655 
16         
 50 1048 452 0.431 9.04 26.0 -2.046 
50         
 50 1047 465 0.444 9.30 26.0 0.868
Positive Control Cyclophosphamide 
1         
 25 526 443 0.842 17.72 26.0 91.277
Trend: 0.203        
Probability: 0.420