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Study Information
Study Attribute Value
CEBS Accession Number: 002-02292-0001-0000-8
Chemical Name: Iodoform
CASRN: 75-47-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 123235_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/20/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 426 0.407 8.52 26.0 0.000
Test Chemical Iodoform 
 0.5       
 50 1045 417 0.399 8.34 26.0 -2.019 
1.6       
 50 1045 436 0.417 8.72 26.0 2.445 
5         
 50 1047 429 0.410 8.58 26.0 0.608 
16         
 50 1046 488 0.467 9.76 26.0 14.554
Positive Control Mitomycin-C 
 0.005     
 50 1050 514 0.490 10.28 26.0 20.198
Trend: 2.041        
Probability: 0.021        

Trial #: 2    Activation: No Activation    Date: 08/24/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 409 0.389 8.18 26.0 0.000
Test Chemical Iodoform 
1.6       
 50 1049 470 0.448 9.40 26.0 15.243 
5         
 50 1051 467 0.444 9.34 26.0 14.290 
16         
 50 1048 489 0.467 9.78 26.0 20.016
Positive Control Mitomycin-C 
 0.005     
 25 526 610 1.160 24.40 26.0 198.289
Trend: 2.521        
Probability: 0.006        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/20/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 461 0.440 9.22 26.0 0.000
Test Chemical Iodoform 
5         
 50 1049 445 0.424 8.90 26.0 -3.655 
16         
 50 1048 452 0.431 9.04 26.0 -2.046 
50         
 50 1047 465 0.444 9.30 26.0 0.868
Positive Control Cyclophosphamide 
1         
 25 526 443 0.842 17.72 26.0 91.277
Trend: 0.203        
Probability: 0.420