Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02292-0002-0000-9 |
Chemical Name: | Iodoform |
CASRN: | 75-47-8 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 123235_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Iodoform | 1.6 | 100 | 8 | 0.080 | 7.0 | 1 | 0.010 | 1.0 | 7 | 0.070 | 6.0 | 0 | 0.000 | 0.0 |
5 | 100 | 7 | 0.070 | 7.0 | 0 | 0.000 | 0.0 | 7 | 0.070 | 7.0 | 0 | 0.000 | 0.0 | ||
16 | 100 | 8 | 0.080 | 7.0 | 2 | 0.020 | 2.0 | 6 | 0.060 | 5.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.15 | 50 | 20 | 0.400 | 32.0 | 7 | 0.140 | 14.0 | 13 | 0.260 | 20.0 | 0 | 0.000 | 0.0 |
Trend: | 1.129 | 0.455 | 1.023 | ||||||||||||
Probability: | 0.129 | 0.325 | 0.153 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 5 | 0.050 | 5.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Iodoform | 5 | 100 | 4 | 0.040 | 4.0 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
16 | 100 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
50 | 100 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 50 | 16 | 0.320 | 30.0 | 4 | 0.080 | 6.0 | 12 | 0.240 | 24.0 | 0 | 0.000 | 0.0 |
Trend: | -0.333 | -0.202 | -0.262 | ||||||||||||
Probability: | 0.630 | 0.580 | 0.603 |