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Study Information
Study Attribute Value
CEBS Accession Number: 002-02298-0001-0000-4
Chemical Name: Iron dextran
CASRN: 9004-66-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 490892
Study Result: Negative


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 86 105 116 45 58
    75 96 118 52
    77 104 146 63
    83 95 176 70
Test Chemical Iron dextran 
1000         
 101 101 125 41 38
    70 92 73 35
  
2000         
 78 98 121 52 51
    86 105 131 51
  
3000         
 81 37 126 52 49
    68 99 95 47
  
4000         
 65 36 73 38 42
    66 22 91 46
  
5000         
 82 71 81 33 27
    72 72 45 21
Positive Control Methyl Methane Sulfonate 
15         
 45 34 149 111 124*
    39 34 161 138

Nonactivation Trial: 2 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 74 84 140 63 46
    99 98 123 41
    97 110 98 34
    101 107 136 45
Test Chemical Iron dextran 
1000         
 122r 113 168 46
    115 100 184 53
  
2000         
 102 93 128 42 38
    103 91 108 35
  
3000         
 79 82 104 44 40
    90 84 96 36
  
4000         
 98 104 134 46 46
    97 89 131 45
  
5000         
 79 95 95 40 41
    72 93 89 41
Positive Control Methyl Methane Sulfonate 
15         
 51 28 182 119 134*
    62 29 276 149

Induced S9 Trial: 1 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 103 101 137 44 40
    113 89 119 35
    98 119 102 35
    87 92 121 46
Test Chemical Iron dextran 
1000         
 97 95 139 48 44
    96 99 115 40
  
2000         
 70 94 71 34 39
    90 84 121 45
  
3000         
 84 87 143 57 52
    79 98 111 47
  
4000         
 73# 77 117 54 61
    80 77 162 68
  
5000         
 83 87 133 53 51
    86 79 124 48
Positive Control 3-Methylcholanthrene 
2.5       
 71 26 686 324 357*
    57 36 665 390

Induced S9 Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 92 103 101 37 28
    99 107 65 22
    83 109 63 25
    93 81 78 28
Test Chemical Iron dextran 
1000         
 95 79 83 29 29
    76 98 64 28
  
2000         
 90 86 79 29 27
    90 89 64 24
  
3000         
 84 80 111 44 35
    94 86 75 27
  
4000         
 89 74 87 33 35
    93 75 105 38
  
5000         
 98 69 130 44 49*
    88 66 144 55
Positive Control 3-Methylcholanthrene 
2.5       
 70 35 581 277 291*
    56 32 510 305

Induced S9 Trial: 3 Experiment Call: Inconclusive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 90 89 62 23 24
    106 104 64 20
    87 102 67 26
    100 106 76 25
Test Chemical Iron dextran 
1000         
 104 113 68 22 18
    112 94 51 15
  
2000         
 81 86 63 26 22
    94 114 50 18
  
3000         
 79 95 47 20 23
    84 102 63 25
  
4000         
 78 64 69 30
    124r 82 56 15
  
5000         
 81 59 63 26 57*
    86 76 228 88
Positive Control 3-Methylcholanthrene 
2.5       
 58 35 328 187 165*
    65 35 282 144

Induced S9 Trial: 4 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 73 86 86 39 39
    69 105 98 47
    75 96 67 30
    62 113 71 38
Test Chemical Iron dextran 
1000         
 76 101 103 45 47
    64# 79 94.5 49
  
2000         
 69 107 80 39 43
    67 109 96 48
  
3000         
 63 81 83 44 48
    67 81 105 52
  
4000         
 71 48 83 39 47
    76# 49 126 56
  
5000         
 80 55 110 46 47
    78 74 111 47
Positive Control 3-Methylcholanthrene 
2.5       
 30 14 276 307 336*
    33 18 361 365

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination