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Study Information
Study Attribute Value
CEBS Accession Number: 002-02302-0001-0000-0
Chemical Name: Isoamyl nitrite
CASRN: 110-46-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 556739_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/01/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 427 0.407 8.54 26.0 0.000
Test Chemical Isoamyl nitrite 
5         
 50 1042 491 0.471 9.82 26.0 15.871 
16         
 50 1052 523 0.497 10.46 26.0 22.250 
50         
 50 1049 598 0.570 11.96 26.0 40.180
Positive Control Mitomycin-C 
 0.005     
 25 526 740 1.407 29.60 26.0 245.945
Trend: 5.358        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/27/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 448 0.427 8.96 26.0 0.000
Test Chemical Isoamyl nitrite 
5         
 50 1046 430 0.411 8.60 26.0 -3.743 
16         
 50 1050 487 0.464 9.74 26.0 8.602 
50         
 50 1047 679 0.649 13.58 26.0 51.852
Positive Control Cyclophosphamide 
1         
 50 1047 878 0.839 17.56 26.0 96.357
Trend: 7.416        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 01/19/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 475 0.453 9.50 26.0 0.000
Test Chemical Isoamyl nitrite 
60         
 50 1043 512 0.491 10.24 26.0 8.306 
80         
 50 1047 508 0.485 10.16 26.0 7.050 
100         
 50 1047 555 0.530 11.10 26.0 16.954
Positive Control Cyclophosphamide 
1         
 50 1046 888 0.849 17.76 26.0 87.305
Trend: 2.282        
Probability: 0.011