COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02302-0002-0000-1
Chemical Name: Isoamyl nitrite
CASRN: 110-46-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 556739_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/27/1982    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Isoamyl nitrite 
16         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
50         
 100 9 0.090 7.0 3 0.030 2.0 6 0.060 5.0 0 0.000 0.0 
160         
 100 19 0.190 14.0 4 0.040 4.0 15 0.150 11.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 21 0.420 28.0 8 0.160 16.0 13 0.260 16.0 0 0.000 0.0
Trend: 3.975 2.218 3.472  
Probability: 0.000 0.013 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/27/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Isoamyl nitrite 
16         
 100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0 
50         
 100 12 0.120 10.0 1 0.010 1.0 11 0.110 9.0 0 0.000 0.0 
160         
 100 12 0.120 11.0 4 0.040 4.0 8 0.080 7.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 28 0.280 21.0 7 0.070 7.0 21 0.210 15.0 0 0.000 0.0
Trend: 1.812 1.843 1.085  
Probability: 0.035 0.033 0.139