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Study Information
Study Attribute Value
CEBS Accession Number: 002-02308-0004-0000-9
Chemical Name: Isobutyl nitrite
CASRN: 542-56-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 841266_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/27/1982    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Isobutyl nitrite 
16         
 100 8 0.080 7.0 2 0.020 2.0 6 0.060 6.0 0 0.000 0.0 
50         
 200 14 0.070 7.0 4 0.020 2.0 10 0.050 5.0 0 0.000 0.0 
160         
 100 10 0.100 10.0 4 0.040 4.0 6 0.060 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 21 0.420 28.0 8 0.160 16.0 13 0.260 16.0 0 0.000 0.0
Trend: 2.474 1.882 1.508  
Probability: 0.007 0.030 0.066  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/27/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Isobutyl nitrite 
50         
 100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0 
160         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
500         
 100 9 0.090 9.0 1 0.010 1.0 8 0.080 8.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 28 0.280 21.0 7 0.070 7.0 21 0.210 15.0 0 0.000 0.0
Trend: 1.013 0.260 0.977  
Probability: 0.156 0.397 0.164