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Study Information
Study Attribute Value
CEBS Accession Number: 002-02310-0001-0000-9
Chemical Name: Isobutyraldehyde
CASRN: 78-84-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 984070_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/30/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 478 0.457 9.56 26.0 18.184
Dimethyl Sulfoxide 
0         
 50 1050 406 0.387 8.12 26.0 0.000
Test Chemical Isobutyraldehyde 
5         
 50 1046 537 0.513 10.74 26.0 32.772 
16         
 50 1050 737 0.702 14.74 26.0 81.527 
50         
 50 1049 1286 1.226 25.72 26.0 217.051 
160         
 50 1047 1918 1.832 38.36 26.0 373.767 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1049 2497 2.380 49.94 26.0 515.611
Mitomycin-C 
 0.01      
 50 1050 2611 2.487 52.22 26.0 543.103
Trend: 38.200        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/18/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 414 0.396 8.28 26.0 1.373
Dimethyl Sulfoxide 
0         
 50 1044 408 0.391 8.16 26.0 0.000
Test Chemical Isobutyraldehyde 
10         
 50 1045 516 0.494 10.32 26.0 26.350 
25         
 50 1045 803 0.768 16.06 26.0 96.625 
50         
 50 1035 960 0.928 19.20 26.0 137.340 
160         
 50 1046 1485 1.420 29.70 26.0 263.275 
250         
 50 1026 2850 2.778 57.00 41.0 610.784 
500         
 50 1036 3743 3.613 74.86 41.0 824.486
Positive Control Mitomycin-C 
 0.005     
 50 1047 1561 1.491 31.22 26.0 281.502
Mitomycin-C 
 0.005     
 50 1048 1480 1.412 29.60 26.0 261.361
Trend: 72.402        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/30/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 435 0.416 8.70 26.0 0.000
Negative (Not Specified) 
0         
 50 1041 388 0.373 7.76 26.0 -10.462
Test Chemical Isobutyraldehyde 
16         
 50 1041 452 0.434 9.04 26.0 4.307 
50         
 50 1044 486 0.466 9.72 26.0 11.831 
160         
 50 1039 620 0.597 12.40 26.0 43.352 
500         
 50 1034 1152 1.114 23.04 26.0 167.645 
1600         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1044 1681 1.610 33.62 26.0 286.807
Cyclophosphamide 
2         
 50 1046 2461 2.353 49.22 26.0 465.206
Trend: 20.384        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/18/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 369 0.353 7.38 26.0 0.000
Negative (Not Specified) 
0         
 50 1034 365 0.353 7.30 26.0 -0.127
Test Chemical Isobutyraldehyde 
500         
 50 1045 1170 1.120 23.40 26.0 216.770 
750         
 50 1040 1301 1.251 26.02 26.0 253.931 
1000         
 50 1032 2269 2.199 45.38 26.0 522.055 
1250         
 50 1032 2906 2.816 58.12 26.0 696.691
Positive Control Cyclophosphamide 
2         
 50 1043 1930 1.850 38.60 26.0 423.537
Cyclophosphamide 
2         
 50 1043 2086 2.000 41.72 26.0 465.854
Trend: 48.319        
Probability: 0.000