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Study Information
Study Attribute Value
CEBS Accession Number: 002-02310-0002-0000-0
Chemical Name: Isobutyraldehyde
CASRN: 78-84-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 984070_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 
Induced Rat Liver S9  2_S9  Questionable 

Trial #:1   Activation: No Activation    Date: 08/02/1983    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Isobutyraldehyde 
16         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
50         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
160         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
500         
 100 15 0.150 12.0 4 0.040 4.0 11 0.110 8.0 0 0.000 0.0 
1600         
 100 35 0.350 27.0 0 0.000 0.0 35 0.350 27.0 0 0.000 0.0 
3000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
4000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 52 0.520 39.0 29 0.290 26.0 23 0.230 17.0 0 0.000 0.0
Trend: 7.850 1.427 7.827  
Probability: 0.000 0.077 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/02/1983    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Isobutyraldehyde 
16         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
50         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
160         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
500         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
1600         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
3000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
4000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 50 0.500 38.0 21 0.210 18.0 29 0.290 24.0 0 0.000 0.0
Trend: 0.224 1.535 -0.471  
Probability: 0.411 0.062 0.681  


Trial #:2   Activation: No Activation    Date: 08/16/1983    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Isobutyraldehyde 
500         
 100 9 0.090 9.0 2 0.020 2.0 7 0.070 7.0 0 0.000 0.0 
1000         
 100 11 0.110 10.0 9 0.090 8.0 2 0.020 2.0 0 0.000 0.0 
1500         
 100 16 0.160 8.0 0 0.000 0.0 15 0.150 7.0 1 0.010 1.0 
2000         
 100 31 0.310 17.0 0 0.000 0.0 31 0.310 17.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 50 0.500 37.0 21 0.210 19.0 29 0.290 23.0 0 0.000 0.0
Trend: 3.545 0.053 3.869  
Probability: 0.000 0.479 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 08/16/1983    Harvest Time: 12 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Isobutyraldehyde 
100         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
250         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
500         
 100 7 0.070 7.0 1 0.010 1.0 6 0.060 6.0 0 0.000 0.0 
750         
 100 14 0.140 14.0 7 0.070 7.0 7 0.070 7.0 0 0.000 0.0 
1000         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
1500         
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
2000         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 60 0.600 40.0 44 0.440 34.0 16 0.160 12.0 0 0.000 0.0
Trend: 2.101 1.756 1.234  
Probability: 0.018 0.040 0.109