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Study Information
Study Attribute Value
CEBS Accession Number: 002-02318-0001-0000-7
Chemical Name: Isophorone
CASRN: 78-59-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 624279_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/28/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 432 0.414 8.64 26.5 0.000
Negative (Not Specified) 
0         
 50 1037 442 0.426 8.84 26.5 2.907
Test Chemical Isophorone 
5         
 50 1032 427 0.414 8.54 26.5 -0.104 
16         
 50 1038 445 0.429 8.90 26.5 3.505 
50         
 50 1042 489 0.469 9.78 26.5 13.303 
160         
 50 1045 451 0.432 9.02 26.5 4.198 
500         
 0 0 0 0.000 0.00 0.0 N/A 
1600         
 0 0 0 0.000 0.00 0.0 N/A 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1044 1312 1.257 26.24 26.5 203.413
Mitomycin-C 
 0.01      
 10 210 823 3.919 82.30 26.5 846.196
Trend: 1.397        
Probability: 0.081        

Trial #: 2    Activation: No Activation    Date: 05/02/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 435 0.416 8.70 26.5 -4.332
Dimethyl Sulfoxide 
0         
 50 1049 456 0.435 9.12 26.5 0.000
Test Chemical Isophorone 
250         
 0 0 0 0.000 0.00 26.5 N/A 
250         
 50 1048 479 0.457 9.58 31.5 5.144 
500         
 0 0 0 0.000 0.00 26.5 N/A 
500         
 50 1047 560 0.535 11.20 31.5 23.042 
750         
 0 0 0 0.000 0.00 31.5 N/A 
750         
 50 1044 632 0.605 12.64 39.0 39.260 
1000         
 50 1043 662 0.635 13.24 39.0 46.011
Positive Control Mitomycin-C 
 0.001     
 50 1050 1302 1.240 26.04 26.5 185.254
Mitomycin-C 
 0.01      
 10 210 749 3.567 74.90 26.5 720.490
Trend: 7.772        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/28/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1038 498 0.480 9.96 26.5 1.987
Dimethyl Sulfoxide 
0         
 50 1048 493 0.470 9.86 26.5 0.000
Test Chemical Isophorone 
50         
 50 1047 437 0.417 8.74 26.5 -11.274 
160         
 50 1036 432 0.417 8.64 26.5 -11.358 
500         
 50 1032 495 0.480 9.90 26.5 1.962 
1600         
 50 1037 539 0.520 10.78 26.5 10.490 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.6       
 50 1048 722 0.689 14.44 26.5 46.450
Cyclophosphamide 
2         
 10 210 253 1.205 25.30 26.5 156.104
Trend: 2.408        
Probability: 0.008        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/02/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 441 0.421 8.82 26.0 0.000
Negative (Not Specified) 
0         
 50 1046 440 0.421 8.80 26.0 -0.131
Test Chemical Isophorone 
160         
 50 1048 463 0.442 9.26 26.0 4.888 
500         
 50 1042 455 0.437 9.10 26.0 3.670 
1000         
 50 1049 461 0.439 9.22 26.0 4.336 
1600         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1048 624 0.595 12.48 26.0 41.362
Cyclophosphamide 
2         
 10 210 340 1.619 34.00 26.0 284.386
Trend: 0.517        
Probability: 0.303