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Study Information
Study Attribute Value
CEBS Accession Number: 002-02318-0010-0000-7
Chemical Name: Isophorone
CASRN: 78-59-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 783723_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 06/11/90 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.90 ± 0.148
Test Chemical Isophorone 
125         
 4 4.43 ± 0.618
  
250         
 4 4.17 ± 0.096
  
500         
 4 5.89 ± 0.769
Positive Control Dimethylbenzanthracene 
2.5       
 4 11.11 ± 0.175


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/27/87 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.35 ± 0.299
Test Chemical Isophorone 
125         
 4 3.49 ± 0.236
  
250         
 4 2.75 ± 0.221
  
500         
 4 3.53 ± 0.504
Positive Control Dimethylbenzanthracene 
2.5       
 4 7.91 ± 1.201


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed