| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02318-0010-0000-7 |
| Chemical Name: | Isophorone |
| CASRN: | 78-59-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 783723_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 06/11/90 | 42 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 42 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Corn Oil | 0 | 4 | 4.90 ± 0.148 | |
| Test Chemical | Isophorone | 125 | 4 | 4.43 ± 0.618 | |
250 | 4 | 4.17 ± 0.096 | |||
500 | 4 | 5.89 ± 0.769 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 | 4 | 11.11 ± 0.175 | |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 01/27/87 | 23 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 23 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Corn Oil | 0 | 4 | 5.35 ± 0.299 | |
| Test Chemical | Isophorone | 125 | 4 | 3.49 ± 0.236 | |
250 | 4 | 2.75 ± 0.221 | |||
500 | 4 | 3.53 ± 0.504 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 | 4 | 7.91 ± 1.201 | |
Footnotes: IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed