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Study Information
Study Attribute Value
CEBS Accession Number: 002-02318-0011-0000-8
Chemical Name: Isophorone
CASRN: 78-59-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 783723_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/27/90 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.8273
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 19.50 ± 2.38 0.0000
Test Chemical Isophorone 
125         
 8 3.00 ± 0.93 0.4162
  
250         
 8 1.75 ± 0.70 0.8299
  
500         
 8 2.00 ± 0.76 0.7570
Vehicle Control No Stressor 
 0         
 8 2.75 ± 1.06 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed