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Study Information
Study Attribute Value
CEBS Accession Number: 002-02324-0001-0000-4
Chemical Name: Isoprene
CASRN: 78-79-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 032841_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/29/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 475 0.460 9.50 26.0 0.000
Test Chemical Isoprene 
50         
 50 1027 373 0.363 7.46 26.0 -21.015 
160         
 50 1034 373 0.361 7.46 26.0 -21.550 
500         
 50 1041 428 0.411 8.56 26.0 -10.587 
1600         
 50 1036 428 0.413 8.56 26.0 -10.156
Positive Control Mitomycin-C 
 0.0E-4    
 50 1039 667 0.642 13.34 26.0 39.610
Mitomycin-C 
 0.005     
 10 207 247 1.193 24.70 26.0 159.498
Trend: -0.736        
Probability: 0.769        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/29/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 398 0.380 7.96 26.0 0.000
Test Chemical Isoprene 
160         
 50 1048 391 0.373 7.82 26.0 -1.853 
500         
 50 1046 347 0.332 6.94 26.0 -12.731 
1600         
 50 1047 390 0.372 7.80 26.0 -2.010 
5000         
 50 1046 391 0.374 7.82 26.0 -1.665
Positive Control Cyclophosphamide 
 0.1       
 50 1049 485 0.462 9.70 26.0 21.627
Cyclophosphamide 
 0.6       
 10 210 137 0.652 13.70 26.0 71.619
Trend: -0.220        
Probability: 0.587