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Study Information
Study Attribute Value
CEBS Accession Number: 002-02334-0001-0000-5
Chemical Name: Isoproterenol hydrochloride
CASRN: 51-30-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 968791_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 10/21/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 100 2098 1012 0.482 10.12 26.0 0.000
Test Chemical Isoproterenol hydrochloride 
 0.4       
 50 1048 513 0.490 10.26 26.0 1.480 
1.3       
 50 1046 444 0.424 8.88 26.0 -12.001 
4         
 50 1047 524 0.500 10.48 26.0 3.755 
13         
 50 1046 607 0.580 12.14 26.0 20.305 
40         
 25 522 412 0.789 16.48 26.0 63.626
Positive Control Triethylenemelamine 
 0.015     
 50 1049 1607 1.532 32.14 26.0 217.589
Trend: 7.135        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/21/1981    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 470 0.451 9.40 26.0 0.000
Test Chemical Isoproterenol hydrochloride 
4         
 50 1042 493 0.473 9.86 26.0 4.894 
13         
 50 1038 483 0.465 9.66 26.0 3.162 
40         
 50 1049 500 0.477 10.00 26.0 5.673 
130         
 50 1048 499 0.476 9.98 26.0 5.562 
400         
 50 1047 548 0.523 10.96 28.0 16.039 
1300         
 100 2085 1096 0.526 10.96 28.0 16.540 
4000         
 50 1046 549 0.525 10.98 28.0 16.362
Positive Control Cyclophosphamide 
1         
 50 1047 1043 0.996 20.86 26.0 120.855
Trend: 3.709        
Probability: 0.000