Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02334-0002-0000-6 |
Chemical Name: | Isoproterenol hydrochloride |
CASRN: | 51-30-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 968791_CA |
Study Result: | Weakly Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Weakly Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 5 | 0.050 | 4.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Isoproterenol hydrochloride | 4 | 100 | 6 | 0.060 | 4.0 | 1 | 0.010 | 1.0 | 5 | 0.050 | 4.0 | 0 | 0.000 | 0.0 |
13 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
40 | 100 | 6 | 0.060 | 6.0 | 1 | 0.010 | 1.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Triethylenemelamine | 0.15 | 100 | 34 | 0.340 | 27.0 | 8 | 0.080 | 7.0 | 26 | 0.260 | 21.0 | 0 | 0.000 | 0.0 |
Trend: | 0.546 | -0.268 | 0.583 | ||||||||||||
Probability: | 0.292 | 0.606 | 0.280 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Isoproterenol hydrochloride | 130 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
400 | 100 | 12 | 0.120 | 11.0 | 5 | 0.050 | 5.0 | 7 | 0.070 | 7.0 | 0 | 0.000 | 0.0 | ||
1300 | 100 | 17 | 0.170 | 10.0 | 6 | 0.060 | 3.0 | 11 | 0.110 | 8.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 0.15 | 100 | 31 | 0.310 | 25.0 | 12 | 0.120 | 12.0 | 17 | 0.170 | 15.0 | 2 | 0.020 | 2.0 |
Trend: | 2.573 | 1.643 | 2.253 | ||||||||||||
Probability: | 0.005 | 0.050 | 0.012 |