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Study Information
Study Attribute Value
CEBS Accession Number: 002-02334-0002-0000-6
Chemical Name: Isoproterenol hydrochloride
CASRN: 51-30-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 968791_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 10/21/1981    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 5 0.050 4.0 1 0.010 1.0 4 0.040 3.0 0 0.000 0.0
Test Chemical: Isoproterenol hydrochloride 
4         
 100 6 0.060 4.0 1 0.010 1.0 5 0.050 4.0 0 0.000 0.0 
13         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
40         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.15      
 100 34 0.340 27.0 8 0.080 7.0 26 0.260 21.0 0 0.000 0.0
Trend: 0.546 -0.268 0.583  
Probability: 0.292 0.606 0.280  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/21/1981    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Isoproterenol hydrochloride 
130         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
400         
 100 12 0.120 11.0 5 0.050 5.0 7 0.070 7.0 0 0.000 0.0 
1300         
 100 17 0.170 10.0 6 0.060 3.0 11 0.110 8.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
 0.15      
 100 31 0.310 25.0 12 0.120 12.0 17 0.170 15.0 2 0.020 2.0
Trend: 2.573 1.643 2.253  
Probability: 0.005 0.050 0.012