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Study Information
Study Attribute Value
CEBS Accession Number: 002-02340-0003-0000-4
Chemical Name: L-Ascorbic acid
CASRN: 50-81-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 395917_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/01/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1039 363 0.349 7.26 26.0 0.000
Test Chemical L-Ascorbic acid 
33         
 50 1045 379 0.363 7.58 26.0 3.808 
111         
 50 1039 403 0.388 8.06 26.0 11.019 
333         
 50 1034 478 0.462 9.56 26.0 32.317 
1111         
 50 1037 641 0.618 12.82 31.0 76.925
Positive Control Mitomycin-C 
 0.001     
 50 1042 646 0.620 12.92 26.0 77.449
Mitomycin-C 
 0.005     
 10 210 323 1.538 32.30 26.0 340.243
Trend: 9.823        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/10/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1045 374 0.358 7.48 26.0 0.000
Test Chemical L-Ascorbic acid 
222         
 50 1046 444 0.424 8.88 26.0 18.603 
333         
 50 1047 513 0.490 10.26 26.0 36.904 
555         
 50 1039 508 0.489 10.16 31.0 36.613 
1111         
 50 1035 579 0.559 11.58 31.0 56.309
Positive Control Mitomycin-C 
 0.001     
 50 1039 748 0.720 14.96 26.0 101.155
Mitomycin-C 
 0.005     
 10 208 277 1.332 27.70 26.0 272.101
Trend: 6.975        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/01/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1038 381 0.367 7.62 26.0 0.000
Test Chemical L-Ascorbic acid 
111         
 50 1047 361 0.345 7.22 26.0 -6.064 
333         
 50 1046 384 0.367 7.68 26.0 0.017 
1111         
 50 1044 442 0.423 8.84 26.0 15.344 
3333         
 50 1047 421 0.402 8.42 26.0 9.549
Positive Control Cyclophosphamide 
 0.125     
 50 1045 545 0.522 10.90 26.0 42.086
Cyclophosphamide 
 0.5       
 10 210 196 0.933 19.60 26.0 154.278
Trend: 2.485        
Probability: 0.006