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Study Information
Study Attribute Value
CEBS Accession Number: 002-02340-0006-0000-7
Chemical Name: L-Ascorbic acid
CASRN: 50-81-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 936928_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 

Trial #:1   Activation: No Activation    Date: 08/04/1987    Harvest Time: 10.4 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: L-Ascorbic acid 
187.5       
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
250         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
625         
 200 6 0.030 2.0 2 0.010 1.0 4 0.020 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 200 22 0.110 8.0 11 0.055 5.0 11 0.055 3.5 0 0.000 0.0
Mitomycin-C 
 0.75      
 25 11 0.440 28.0 4 0.160 12.0 7 0.280 16.0 0 0.000 0.0
Trend: 1.993 0.927 2.134  
Probability: 0.023 0.177 0.016  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/04/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 5 0.025 2.0 0 0.000 0.0 5 0.025 2.0 0 0.000 0.0
Test Chemical: L-Ascorbic acid 
2500         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
3750         
 200 4 0.020 2.0 4 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
5000         
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 23 0.115 11.0 5 0.025 2.5 18 0.090 9.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 11 0.440 36.0 5 0.200 20.0 6 0.240 16.0 0 0.000 0.0
Trend: 0.887 0.775 0.542  
Probability: 0.188 0.219 0.294  


Trial #:2   Activation: No Activation    Date: 09/23/1987    Harvest Time: 10.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: L-Ascorbic acid 
50         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
100         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
250         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 200 23 0.115 10.0 13 0.065 4.5 10 0.050 4.5 0 0.000 0.0
Mitomycin-C 
 0.75      
 25 13 0.520 40.0 6 0.240 16.0 7 0.280 24.0 0 0.000 0.0
Trend: -0.589 -0.680 -0.204  
Probability: 0.722 0.752 0.581