| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02340-0016-0000-8 |
| Chemical Name: | L-Ascorbic acid |
| CASRN: | 50-81-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 592095_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 06/01/88 | 23 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 23 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Phosphate Buffered Saline | 0 | 4 | 5.74 ± 0.197 | |
| Test Chemical | L-Ascorbic acid | 550 | 4 | 7.07 ± 0.314 | |
1100 | 4 | 7.93 ± 0.606 | |||
2200 | 4 | 7.82 ± 0.393 | |||
| Positive Control | Mitomycin-C | 0.5 | 4 | 10.54 ± 1.502 | |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 07/20/88 | 42 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 42 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Phosphate Buffered Saline | 0 | 4 | 5.20 ± 0.204 | |
| Test Chemical | L-Ascorbic acid | 500 | 4 | 5.41 ± 0.280 | |
1000 | 4 | 6.22 ± 0.295 | |||
2000 | 4 | 6.09 ± 0.120 | |||
| Positive Control | Mitomycin-C | 0.5 | 4 | 10.53 ± 0.545 | |
Footnotes: IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed