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Study Information
Study Attribute Value
CEBS Accession Number: 002-02340-0016-0000-8
Chemical Name: L-Ascorbic acid
CASRN: 50-81-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 592095_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 06/01/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 5.74 ± 0.197
Test Chemical L-Ascorbic acid 
550         
 4 7.07 ± 0.314
  
1100         
 4 7.93 ± 0.606
  
2200         
 4 7.82 ± 0.393
Positive Control Mitomycin-C 
 0.5       
 4 10.54 ± 1.502


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/20/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 5.20 ± 0.204
Test Chemical L-Ascorbic acid 
500         
 4 5.41 ± 0.280
  
1000         
 4 6.22 ± 0.295
  
2000         
 4 6.09 ± 0.120
Positive Control Mitomycin-C 
 0.5       
 4 10.53 ± 0.545


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed