Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02343-0002-0000-6 |
Chemical Name: | L-Tryptophan |
CASRN: | 73-22-3 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 702434_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Medium | 0 | 200 | 4 | 0.020 | 1.5 | 1 | 0.005 | 0.5 | 3 | 0.015 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | L-Tryptophan | 300 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
500 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
1000 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.125 | 200 | 42 | 0.210 | 16.0 | 14 | 0.070 | 6.0 | 28 | 0.140 | 11.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 21 | 0.420 | 40.0 | 11 | 0.220 | 22.0 | 10 | 0.200 | 20.0 | 0 | 0.000 | 0.0 | |
Trend: | -1.514 | -0.691 | -0.807 | ||||||||||||
Probability: | 0.935 | 0.755 | 0.790 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Medium | 0 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Test Chemical: | L-Tryptophan | 300 | 200 | 5 | 0.025 | 2.5 | 1 | 0.005 | 0.5 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
500 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
1000 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 20 | 0.100 | 9.5 | 6 | 0.030 | 2.5 | 14 | 0.070 | 7.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 26 | 0.520 | 42.0 | 6 | 0.120 | 12.0 | 20 | 0.400 | 34.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.891 | -0.419 | -0.800 | ||||||||||||
Probability: | 0.813 | 0.662 | 0.788 |