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Study Information
Study Attribute Value
CEBS Accession Number: 002-02347-0001-0000-9
Chemical Name: Lasiocarpine
CASRN: 303-34-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 256879_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/03/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1029 506 0.492 10.12 26.0 0.000
Test Chemical Lasiocarpine 
50         
 50 1028 523 0.509 10.46 26.0 3.460 
167         
 50 1010 555 0.550 11.10 26.0 11.747 
500         
 50 1015 670 0.660 13.40 33.0 34.237 
1670         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1034 671 0.649 13.42 26.0 31.967
Mitomycin-C 
 0.01      
 5 103 194 1.883 38.80 26.0 283.027
Trend: 5.211        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 01/03/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1026 407 0.397 8.14 26.0 0.000
Test Chemical Lasiocarpine 
100         
 50 1015 584 0.575 11.68 34.5 45.044 
200         
 50 1013 675 0.666 13.50 34.5 67.976 
400         
 0 0 0 0.000 0.00 34.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1022 553 0.541 11.06 26.0 36.404
Mitomycin-C 
 0.01      
 5 105 210 2.000 42.00 26.0 404.177
Trend: 8.248        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/04/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 527 0.509 10.54 26.0 0.000
Test Chemical Lasiocarpine 
5         
 5 103 297 2.883 59.40 26.0 466.850 
16.7       
 5 103 458 4.447 91.60 26.0 774.133 
50         
 5 105 683 6.505 136.60 33.0 1178.735 
167         
 0 0 0 0.000 0.00 33.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1041 929 0.892 18.58 26.0 75.434
Cyclophosphamide 
2         
 5 101 215 2.129 43.00 26.0 318.472
Trend: 56.893        
Probability: 0.000