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Study Information
Study Attribute Value
CEBS Accession Number: 002-02347-0002-0000-0
Chemical Name: Lasiocarpine
CASRN: 303-34-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 256879_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 01/16/1985    Harvest Time: 21.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 3.0 0 0.000 0.0 4 0.040 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 2.0 1 0.010 1.0 3 0.030 1.0 0 0.000 0.0
Test Chemical: Lasiocarpine 
100         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
247         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
500         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
750         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 20 0.800 60.0 1 0.040 4.0 19 0.760 60.0 0 0.000 0.0
Trend: -1.321 -1.307 -0.767  
Probability: 0.907 0.904 0.779  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/13/1985    Harvest Time: 21.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Lasiocarpine 
500         
 10 44 4.400 80.0 10 1.000 40.0 14 1.400 70.0 20 2.000 20.0 
750         
 10 62 6.200 100.0 15 1.500 50.0 7 0.700 30.0 40 4.000 40.0 
1000         
 10 65 6.500 100.0 9 0.900 30.0 6 0.600 30.0 50 5.000 50.0 
1250         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 19 0.190 9.0 5 0.050 5.0 4 0.040 4.0 10 0.100 1.0
Cyclophosphamide 
12.5       
 25 18 0.720 44.0 11 0.440 36.0 7 0.280 16.0 0 0.000 0.0
Trend: 9.650 4.759 4.886  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/16/1985    Harvest Time: 21.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Lasiocarpine 
100         
 10 20 2.000 70.0 7 0.700 40.0 13 1.300 60.0 0 0.000 0.0 
247         
 10 56 5.600 100.0 14 1.400 60.0 29 2.900 80.0 13 1.300 20.0 
500         
 10 53 5.300 100.0 20 2.000 90.0 20 2.000 130.0 13 1.300 20.0 
750         
 10 68 6.800 100.0 12 1.200 60.0 16 1.600 110.0 40 4.000 40.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 26 0.260 20.0 14 0.140 12.0 12 0.120 10.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 43 1.720 80.0 17 0.680 32.0 26 1.040 68.0 0 0.000 0.0
Trend: 10.653 8.641 11.678  
Probability: 0.000 0.000 0.000