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Study Information
Study Attribute Value
CEBS Accession Number: 002-02349-0001-0000-1
Chemical Name: Lauric acid diethanolamine condensate
CASRN: 120-40-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 836554_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/09/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Solvent 
0         
 50 1049 342 0.326 6.84 26.0 0.000
Test Chemical Lauric acid diethanolamine condensate 
2.49      
 50 1042 427 0.410 8.54 26.0 25.693 
4.97      
 50 1029 461 0.448 9.22 26.0 37.415 
14.9       
 50 1037 467 0.450 9.34 26.0 38.130 
49.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1041 567 0.545 11.34 26.0 67.064
Mitomycin-C 
 0.01      
 10 208 243 1.168 24.30 26.0 258.338
Trend: 4.594        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/23/1988    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Solvent 
0         
 50 1044 348 0.333 6.96 26.0 0.000
Test Chemical Lauric acid diethanolamine condensate 
5         
 50 1044 403 0.386 8.06 26.0 15.805 
10         
 50 1046 398 0.380 7.96 26.0 14.149 
15         
 50 1041 365 0.351 7.30 26.0 5.187 
20         
 50 1043 443 0.425 8.86 26.0 27.421 
30         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1028 722 0.702 14.44 26.0 110.700
Mitomycin-C 
 0.01      
 10 208 420 2.019 42.00 26.0 505.769
Trend: 2.236        
Probability: 0.013        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/04/1986    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Solvent 
0         
 50 1023 457 0.447 9.14 26.0 0.000
Test Chemical Lauric acid diethanolamine condensate 
2.5       
 50 1030 477 0.463 9.54 26.0 3.667 
8.35      
 50 1026 455 0.443 9.10 26.0 -0.729 
25         
 50 1041 435 0.418 8.70 26.0 -6.460 
83.5       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1034 535 0.517 10.70 26.0 15.822
Cyclophosphamide 
2.5       
 10 208 224 1.077 22.40 26.0 141.071
Trend: -1.142        
Probability: 0.873        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/01/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Solvent 
0         
 50 1034 566 0.547 11.32 26.0 0.000
Test Chemical Lauric acid diethanolamine condensate 
10         
 50 1029 693 0.673 13.86 26.0 23.033 
15         
 50 1030 689 0.669 13.78 26.0 22.204 
20         
 50 1031 702 0.681 14.04 26.0 24.389 
30         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.75      
 50 1032 728 0.705 14.56 26.0 28.871
Cyclophosphamide 
2.5       
 20 414 520 1.256 26.00 26.0 129.460
Trend: 3.599        
Probability: 0.000