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Study Information
Study Attribute Value
CEBS Accession Number: 002-02349-0018-0000-9
Chemical Name: Lauric acid diethanolamine condensate
CASRN: 120-40-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 920902
Study Result: Negative


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative
  Conc.
ug/mL
Cloning
Efficiency
Relative Total
Growth
Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol
 0         
59 98 72 40 36
    64 88 83 43
    46r 83 49 36
    73 113 53 24
Test Chemical Lauric acid diethanolamine condensate
2.5       
50 97 46 31 28
    34 69 27 26
    47 94 38 27
 
5         
68 112 86 42 40
    63 112 55 29
    45 67 65 48
 
10         
90 132 74 27 26
    88 142 45 17
    93 149 91 33
 
20         
101 142 67 22 24
    88 101 62 23
    80 94 61 25
 
30         
88 100 54 21 33
    52 13 89 57
    83# 119 53 21
 
40         
54 12 60 37 43
    44 29 44 33
    49 24 86 59
Positive Control Methyl Methane Sulfonate
5         
60 72 433 240 157*
    76 83 379 167
    93 116 178 64

Nonactivation Trial: 2 Experiment Call: Rejected
  Conc.
ug/mL
Cloning
Efficiency
Relative Total
Growth
Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol
 0         
119# 111 70 20 17
    95 91 65 23
    92 88 46 17
    99 110 26 9
Test Chemical Lauric acid diethanolamine condensate
5         
75 80 78 35 34*
    91 89 77 28
    81 75 94 39
 
10         
126r 82 103 27 28*
    116 111 97 28
    84 78 72 29
 
20         
89 60 91 34 32*
    107 66 91 28
    87 58 90 34
 
30         
84 45 67 27 28*
    84 49 98 39
    99 53 58 20
 
40         
33*
    56 5 56 34
    86 14 83 32
 
50         
   
   
Positive Control Methyl Methane Sulfonate
5         
67 32 544 269 199*
    59 39 467 263
    48 31 93 65

Nonactivation Trial: 3 Experiment Call: Negative
  Conc.
ug/mL
Cloning
Efficiency
Relative Total
Growth
Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol
 0         
115# 130 292 85 62
    111 97 217 65
    117 112 141 40
    106 60 183 58
Test Chemical Lauric acid diethanolamine condensate
5         
118 94 194 55 57
    105 80 204 65
    118 77 185 52
 
10         
115 91 137 40 65
    111 66 206 62
    47 36 131 94
 
20         
108 29 296 91 60
    115 50 144 42
    119 55 169 47
 
30         
   
 
40         
   
   
Positive Control Methyl Methane Sulfonate
5         
77 43 900 390 475*
    39 28 847 721
    98# 59 924 315

Induced S9 Trial: 1 Experiment Call: Negative
  Conc.
ug/mL
Cloning
Efficiency
Relative Total
Growth
Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol
 0         
88# 100 113 43 52
    69# 99 137 66
    81 103 106 44
    73# 98 121 55
Test Chemical Lauric acid diethanolamine condensate
5         
76 68 132 58 55
    91 75 145 53
    91 84 143 52
 
10         
81 79 169 69 60
    95# 94 147 51
 
20         
85 74 131 51 53
    106 78 174 55
    98 57 157 53
 
30         
77 65 114 50 61
    97 61 196 67
    86 65 170 66
 
40         
80# 43 107 45 54
    93# 64 124 45
    68 29 152 74
 
50         
101 21 205 68 62
    63# 8 105 56
 
60         
   
   
Positive Control 3-Methylcholanthrene
2.5       
70# 56 365 175 187*
    102# 76 474 155
    79# 48 546 231

Induced S9 Trial: 2 Experiment Call: Negative
  Conc.
ug/mL
Cloning
Efficiency
Relative Total
Growth
Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol
 0         
110 98 144 44 40
    120r 79 186 52
    114 102 121 36
Test Chemical Lauric acid diethanolamine condensate
5         
81 59 149 61 53
    104 98 141 45
    107 97 164 51
 
10         
115# 87 171 50 49
    114 66 162 47
    124r 69 168 45
 
20         
89# 61 154 58 51
    112 54 147 44
    128r 25 110 29
 
30         
96 41 146 51 41
    117 33 144 41
    90# 13 86 32
 
40         
   
   
Positive Control 3-Methylcholanthrene
2.5       
88# 37 741 281 293*
    122r 61 722 198
    103 38 942 305

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination