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Study Information
Study Attribute Value
CEBS Accession Number: 002-02356-0001-0000-9
Chemical Name: Lead dimethyldithiocarbamate
CASRN: 19010-66-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 615571_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/09/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 422 0.401 8.44 26.0 0.000
Dimethyl Sulfoxide 
0         
 50 1049 430 0.410 8.60 31.0 2.187
Test Chemical Lead dimethyldithiocarbamate 
 0.003     
 50 1045 406 0.389 8.12 26.0 -3.147 
 0.01      
 50 1050 417 0.397 8.34 26.0 -0.997 
 0.033     
 50 1047 424 0.405 8.48 31.0 0.954 
 0.1       
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1049 586 0.559 11.72 26.0 39.260
Mitomycin-C 
 0.004     
 10 210 231 1.100 23.10 26.0 174.218
Trend: 0.233        
Probability: 0.408        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/07/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 402 0.382 8.04 31.0 -5.055
Dimethyl Sulfoxide 
0         
 50 1051 423 0.402 8.46 26.0 0.000
Test Chemical Lead dimethyldithiocarbamate 
 0.2       
 50 1049 386 0.368 7.72 26.0 -8.573 
 0.67      
 50 1044 407 0.390 8.14 26.0 -3.137 
2         
 50 1047 463 0.442 9.26 31.0 9.874 
6.7       
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1049 590 0.562 11.80 26.0 39.746
Cyclophosphamide 
 0.5       
 10 211 213 1.009 21.30 26.0 150.818
Trend: 1.583        
Probability: 0.057