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Study Information
Study Attribute Value
CEBS Accession Number: 002-02356-0003-0000-1
Chemical Name: Lead dimethyldithiocarbamate
CASRN: 19010-66-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 962975_SCE
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Test Failure 
No Activation  3  Test Failure 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Test Failure 

Trial #: 1    Activation: No Activation    Date: 12/28/1982    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 25 522 240 0.460 9.60 26.0 -24.647
Dimethyl Sulfoxide 
0         
 50 1044 637 0.610 12.74 26.0 0.000
Test Chemical Lead dimethyldithiocarbamate 
 0.0015    
 50 1044 539 0.516 10.78 26.0 -15.385 
 0.005     
 50 1044 554 0.531 11.08 26.0 -13.030 
 0.015     
 50 1034 644 0.623 12.88 32.0 2.077 
 0.5       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1042 747 0.717 14.94 26.0 17.494
Mitomycin-C 
 0.01      
 5 103 227 2.204 45.40 26.0 261.202
Trend: -0.060        
Probability: 0.524        

Trial #: 2    Activation: No Activation    Date: 02/01/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 588 0.559 11.76 26.0 0.000
Test Chemical Lead dimethyldithiocarbamate 
 0.025     
 50 1045 590 0.565 11.80 26.0 1.012
Positive Control Mitomycin-C 
 0.001     
 50 1045 776 0.743 15.52 26.0 32.857
Mitomycin-C 
 0.01      
 5 103 257 2.495 51.40 26.0 346.410
Trend: 0.000        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 02/17/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 517 0.494 10.34 25.5 -19.120
Dimethyl Sulfoxide 
0         
 50 1045 638 0.611 12.76 25.5 0.000
Test Chemical Lead dimethyldithiocarbamate 
 0.015     
 50 1044 738 0.707 14.76 34.3 15.785 
 0.02      
 50 1048 789 0.753 15.78 34.3 23.314 
 0.03      
 50 1038 822 0.792 16.44 34.3 29.709
Positive Control Mitomycin-C 
 0.001     
 50 1051 840 0.799 16.80 25.5 30.910
Mitomycin-C 
 0.01      
 5 104 246 2.365 49.20 25.5 287.434
Trend: 5.004        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/01/1983    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1053 611 0.580 12.22 26.0 0.000
Test Chemical Lead dimethyldithiocarbamate 
 0.5       
 50 1048 652 0.622 13.04 26.0 7.219 
1         
 50 1046 705 0.674 14.10 26.0 16.157 
1.5       
 50 1044 723 0.693 14.46 33.8 19.351
Positive Control Cyclophosphamide 
 0.35      
 50 1048 766 0.731 15.32 26.0 25.966
Cyclophosphamide 
2         
 5 106 181 1.708 36.20 26.0 194.279
Trend: 3.554        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/28/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1024 560 0.547 11.20 26.0 -1.506
Dimethyl Sulfoxide 
0         
 50 1041 578 0.555 11.56 26.0 0.000
Test Chemical Lead dimethyldithiocarbamate 
1.5       
 50 1044 617 0.591 12.34 26.0 6.441 
5         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.35      
 50 1049 757 0.722 15.14 26.0 29.970
Cyclophosphamide 
2         
 5 105 176 1.676 35.20 26.0 201.888
Trend: 1.078        
Probability: 0.140