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Study Information
Study Attribute Value
CEBS Accession Number: 002-02356-0004-0000-2
Chemical Name: Lead dimethyldithiocarbamate
CASRN: 19010-66-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 962975_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 03/01/1983    Harvest Time: 22 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 6 0.060 6.0 2 0.020 2.0 0 0.000 0.0 4 0.040 4.0
Dimethyl Sulfoxide 
0         
 100 6 0.060 6.0 4 0.040 4.0 0 0.000 0.0 2 0.020 2.0
Test Chemical: Lead dimethyldithiocarbamate 
 0.025     
 100 9 0.090 8.0 4 0.040 4.0 2 0.020 2.0 3 0.030 3.0 
 0.03      
 100 13 0.130 11.0 3 0.030 3.0 4 0.040 3.0 6 0.060 6.0 
 0.04      
 100 26 0.260 23.0 12 0.120 12.0 4 0.040 3.0 10 0.100 10.0 
 0.05      
 100 69 0.690 35.0 20 0.200 15.0 31 0.310 17.0 18 0.180 9.0
Positive Control: Mitomycin-C 
 0.05      
 50 27 0.540 34.0 15 0.300 22.0 12 0.240 18.0 0 0.000 0.0
Trend: 6.289 3.694 5.102  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/01/1983    Harvest Time: 22 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 5.0 2 0.020 2.0 2 0.020 2.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 8 0.080 8.0 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0
Test Chemical: Lead dimethyldithiocarbamate 
1.5       
 100 31 0.310 13.0 5 0.050 5.0 4 0.040 4.0 22 0.220 4.0 
1.75      
 100 60 0.600 29.0 25 0.250 19.0 19 0.190 17.0 16 0.160 7.0 
2         
 100 91 0.910 43.0 29 0.290 20.0 28 0.280 20.0 34 0.340 16.0
Positive Control: Cyclophosphamide 
10         
 50 20 0.400 28.0 9 0.180 14.0 5 0.100 8.0 6 0.120 12.0
Trend: 6.400 4.303 5.412  
Probability: 0.000 0.000 0.000