Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-02359-0003-0000-4
Chemical Name: Lead sulfide
CASRN: 1314-87-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A89452_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/11/92 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.3646
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 4.75 ± 0.65 0.0008
  
200         
 8 7.00 ± 2.04 0.0000
Test Chemical Lead sulfide 
500         
 8 1.00 ± 0.76 0.5000
  
1000         
 8 0.75 ± 0.53 0.6479
  
2000         
 8 1.50 ± 0.50 0.2622
  
3000         
 8 1.00 ± 0.53 0.5000
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.38 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/26/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.4697
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 4.25 ± 1.10 0.0002
  
200         
 8 7.25 ± 2.10 0.0000
Test Chemical Lead sulfide 
500         
 8 0.00 ± 0.00 0.9216
  
1000         
 8 0.00 ± 0.00 0.9216
  
2000         
 8 1.00 ± 0.53 0.2062
  
3000         
 8 0.00 ± 0.00 0.9216
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed