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Study Information
Study Attribute Value
CEBS Accession Number: 002-02359-0003-0000-4
Chemical Name: Lead sulfide
CASRN: 1314-87-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A89452_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/11/92 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.3646
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 4.75 ± 0.65 0.0008
  
200         
 8 7.00 ± 2.04 0.0000
Test Chemical Lead sulfide 
500         
 8 1.00 ± 0.76 0.5000
  
1000         
 8 0.75 ± 0.53 0.6479
  
2000         
 8 1.50 ± 0.50 0.2622
  
3000         
 8 1.00 ± 0.53 0.5000
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.38 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/26/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.4697
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 4.25 ± 1.10 0.0002
  
200         
 8 7.25 ± 2.10 0.0000
Test Chemical Lead sulfide 
500         
 8 0.00 ± 0.00 0.9216
  
1000         
 8 0.00 ± 0.00 0.9216
  
2000         
 8 1.00 ± 0.53 0.2062
  
3000         
 8 0.00 ± 0.00 0.9216
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed