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Study Information
Study Attribute Value
CEBS Accession Number: 002-02366-0001-0000-0
Chemical Name: Lindane
CASRN: 58-89-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 931320_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/27/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 468 0.447 9.36 26.0 0.000
Test Chemical Lindane 
1.6       
 50 1049 440 0.419 8.80 26.0 -6.073 
5         
 50 1051 421 0.401 8.42 26.0 -10.300 
16         
 50 1047 404 0.386 8.08 26.0 -13.593
Positive Control Mitomycin-C 
 0.005     
 50 1047 863 0.824 17.26 26.0 84.578
Trend: -2.263        
Probability: 0.988        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/27/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 490 0.466 9.80 26.0 0.000
Test Chemical Lindane 
5         
 50 1048 517 0.493 10.34 26.0 5.812 
16         
 50 1049 535 0.510 10.70 26.0 9.392 
50         
 50 1049 471 0.449 9.42 26.0 -3.694
Positive Control Cyclophosphamide 
1         
 50 1050 805 0.767 16.10 26.0 64.442
Trend: -0.358        
Probability: 0.640