COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02366-0002-0000-1
Chemical Name: Lindane
CASRN: 58-89-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 931320_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/04/1983    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Lindane
5         
100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0
16         
100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0
50         
100 8 0.080 8.0 1 0.010 1.0 7 0.070 7.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.15      
50 32 0.640 40.0 10 0.200 20.0 22 0.440 24.0 0 0.000 0.0
Trend: 0.862 0.610 0.641  
Probability: 0.194 0.271 0.261  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/27/1983    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Lindane
5         
100 7 0.070 6.0 1 0.010 1.0 6 0.060 5.0 0 0.000 0.0
16         
100 8 0.080 8.0 4 0.040 4.0 4 0.040 4.0 0 0.000 0.0
50         
100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Cyclophosphamide
15         
50 16 0.320 28.0 7 0.140 14.0 9 0.180 18.0 0 0.000 0.0
Trend: 0.192 0.009 0.214  
Probability: 0.424 0.496 0.415