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Study Information
Study Attribute Value
CEBS Accession Number: 002-02380-0001-0000-6
Chemical Name: Malaoxon
CASRN: 1634-78-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 725067_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 07/18/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1034 474 0.458 9.48 26.0 0.000
Test Chemical Malaoxon 
16.7       
 50 1021 522 0.511 10.44 26.0 11.529 
50         
 50 1017 573 0.563 11.46 26.0 22.907 
167         
 50 1020 846 0.829 16.92 26.0 80.931 
500         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1007 505 0.501 10.10 26.0 9.397
Mitomycin-C 
 0.01      
 5 103 191 1.854 38.20 26.0 304.518
Trend: 10.937        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/07/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 431 0.417 8.62 26.0 0.000
Test Chemical Malaoxon 
50         
 50 1020 524 0.514 10.48 26.0 23.127 
124         
 50 1036 748 0.722 14.96 26.0 73.047 
168         
 25 500 456 0.912 18.24 26.0 118.584 
251         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1022 540 0.528 10.80 26.0 26.639
Mitomycin-C 
 0.01      
 5 101 177 1.752 35.40 26.0 320.025
Trend: 12.961        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/18/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1009 447 0.443 8.94 26.0 0.000
Test Chemical Malaoxon 
167         
 50 1023 432 0.422 8.64 26.0 -4.678 
500         
 50 1032 460 0.446 9.20 26.0 0.615 
1670         
 50 1016 715 0.704 14.30 26.0 58.853 
5000         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1018 579 0.569 11.58 26.0 28.385
Cyclophosphamide 
2         
 5 104 238 2.288 47.60 26.0 416.568
Trend: 8.198        
Probability: 0.000