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Study Information
Study Attribute Value
CEBS Accession Number: 002-02380-0002-0000-7
Chemical Name: Malaoxon
CASRN: 1634-78-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 725067_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Weakly Positive* 
Induced Rat Liver S9  3_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/13/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 3 0.015 2.0 1 0.005 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Malaoxon 
187         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0 
249         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0 
377         
 200 3 0.015 2.0 2 0.010 1.0 1 0.005 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 200 7 0.035 4.0 5 0.025 3.0 2 0.010 1.0 0 0.000 0.0
Mitomycin-C 
 0.5       
 25 8 0.320 28.0 3 0.120 12.0 5 0.200 16.0 0 0.000 0.0
Trend: 0.894 1.989 0.000  
Probability: 0.186 0.023 0.500  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/13/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 2.0 2 0.010 1.0 3 0.015 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0
Test Chemical: Malaoxon 
502         
 200 3 0.015 2.0 2 0.010 1.0 1 0.005 1.0 0 0.000 0.0 
1256         
 200 6 0.030 3.0 3 0.015 2.0 3 0.015 2.0 0 0.000 0.0 
2512         
 200 5 0.025 2.0 1 0.005 1.0 4 0.020 2.0 0 0.000 0.0 
3750         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 12 0.060 6.0 6 0.030 3.0 6 0.030 3.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 13 0.520 28.0 4 0.160 16.0 9 0.360 20.0 0 0.000 0.0
Trend: 0.923 0.332 2.002  
Probability: 0.178 0.370 0.023  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/23/1985    Harvest Time: 21.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 3.0 0 0.000 0.0 5 0.025 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Malaoxon 
1998         
 200 3 0.015 2.0 0 0.000 0.0 3 0.015 2.0 0 0.000 0.0 
2498         
 200 5 0.025 3.0 1 0.005 1.0 4 0.020 2.0 0 0.000 0.0 
3010         
 50 22 0.440 18.0 5 0.100 8.0 7 0.140 12.0 10 0.200 2.0 
3500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 12 0.060 5.0 5 0.025 3.0 7 0.035 3.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 11 0.440 36.0 5 0.200 20.0 6 0.240 24.0 0 0.000 0.0
Trend: 4.322 2.528 3.012  
Probability: 0.000 0.006 0.001  


Trial #:3_S9   Activation: Induced Rat Liver S9    Date: 01/28/1986    Harvest Time: 21 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 7 0.035 3.0 0 0.000 0.0 7 0.035 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 7 0.035 3.0 2 0.010 1.0 5 0.025 2.0 0 0.000 0.0
Test Chemical: Malaoxon 
3000         
 200 3 0.015 1.0 2 0.010 1.0 1 0.005 1.0 0 0.000 0.0 
3250         
 200 9 0.045 4.0 5 0.025 3.0 4 0.020 2.0 0 0.000 0.0 
3500         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 24 0.120 11.0 5 0.025 3.0 19 0.095 9.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 8 0.320 24.0 4 0.160 16.0 4 0.160 16.0 0 0.000 0.0
Trend: -0.609 -0.245 -0.508  
Probability: 0.729 0.597 0.694