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Study Information
Study Attribute Value
CEBS Accession Number: 002-02380-0022-0000-9
Chemical Name: Malaoxon
CASRN: 1634-78-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635239_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/13/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.7540
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 12.50 ± 2.03 0.0000
Test Chemical Malaoxon 
7.5       
 8 3.75 ± 1.10 0.1548
  
15         
 8 2.00 ± 0.38 0.6832
  
30         
 8 2.25 ± 0.96 0.5918
Vehicle Control No Stressor 
 0         
 8 2.50 ± 1.12 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 10/01/91 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.4002
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 25.00 ± 3.95 0.0000
Test Chemical Malaoxon 
5         
 8 2.75 ± 0.65 0.4125
  
10         
 8 3.50 ± 1.12 0.2035
  
20         
 8 2.75 ± 0.65 0.4125
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.73 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed