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Study Information
Study Attribute Value
CEBS Accession Number: 002-02383-0001-0000-9
Chemical Name: Maleic hydrazide
CASRN: 123-33-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 667373_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/11/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1042 344 0.330 6.88 26.5 -4.741
Dimethyl Sulfoxide 
0         
 50 1033 358 0.347 7.16 26.5 0.000
Test Chemical Maleic hydrazide 
1.6       
 50 1032 415 0.402 8.30 26.5 16.034 
8         
 50 1036 411 0.397 8.22 26.5 14.472 
40         
 50 1031 351 0.340 7.02 26.5 -1.765 
200         
 50 1044 555 0.532 11.10 26.5 53.394 
1000         
 50 1034 1416 1.369 28.32 26.5 295.148
Positive Control Triethylenemelamine 
 0.015     
 50 1037 1571 1.515 31.42 26.5 337.134
Trend: 27.840        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/01/1980    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1037 313 0.302 6.26 26.5 -4.389
Dimethyl Sulfoxide 
0         
 50 1039 328 0.316 6.56 26.5 0.000
Test Chemical Maleic hydrazide 
1.6       
 50 1006 330 0.328 6.60 26.5 3.910 
8         
 50 1029 359 0.349 7.18 26.5 10.515 
40         
 50 1020 325 0.319 6.50 26.5 0.931 
200         
 50 1026 361 0.352 7.22 26.5 11.456 
1000         
 50 1024 313 0.306 6.26 26.5 -3.175
Positive Control Cyclophosphamide 
1.5       
 50 1044 1317 1.261 26.34 26.5 299.601
Trend: -0.053        
Probability: 0.521