Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02383-0002-0000-0 |
Chemical Name: | Maleic hydrazide |
CASRN: | 123-33-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 667373_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Maleic hydrazide | 0.1 | 100 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
1 | 100 | 3 | 0.030 | 3.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
10 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
100 | 100 | 6 | 0.060 | 6.0 | 4 | 0.040 | 4.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
1000 | 100 | 7 | 0.070 | 5.0 | 2 | 0.020 | 2.0 | 5 | 0.050 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Triethylenemelamine | 0.5 | 100 | 22 | 0.220 | 18.0 | 14 | 0.140 | 12.0 | 8 | 0.080 | 7.0 | 0 | 0.000 | 0.0 |
Trend: | 1.756 | 0.317 | 2.560 | ||||||||||||
Probability: | 0.040 | 0.376 | 0.005 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 5 | 0.050 | 5.0 | 2 | 0.020 | 2.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Maleic hydrazide | 0.1 | 100 | 7 | 0.070 | 2.0 | 1 | 0.010 | 1.0 | 6 | 0.060 | 2.0 | 0 | 0.000 | 0.0 |
1 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
10 | 100 | 5 | 0.050 | 4.0 | 0 | 0.000 | 0.0 | 5 | 0.050 | 4.0 | 0 | 0.000 | 0.0 | ||
100 | 100 | 4 | 0.040 | 4.0 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
1000 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 25 | 100 | 16 | 0.160 | 16.0 | 4 | 0.040 | 4.0 | 10 | 0.100 | 10.0 | 2 | 0.020 | 2.0 |
Trend: | 1.148 | 1.175 | 0.341 | ||||||||||||
Probability: | 0.125 | 0.120 | 0.366 |