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Study Information
Study Attribute Value
CEBS Accession Number: 002-02383-0004-0000-2
Chemical Name: Maleic hydrazide
CASRN: 123-33-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 702766_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 01/01/1982    Harvest Time: 11 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Maleic hydrazide 
500         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1500         
 100 6 0.060 6.0 6 0.060 6.0 0 0.000 0.0 0 0.000 0.0 
2000         
 100 23 0.230 21.0 19 0.190 17.0 1 0.010 1.0 3 0.030 3.0 
3000         
 100 12 0.120 9.0 6 0.060 5.0 5 0.050 5.0 1 0.010 1.0 
4000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 55 0.550 40.0 36 0.360 31.0 11 0.110 10.0 8 0.080 8.0
Trend: 4.615 4.041 1.997  
Probability: 0.000 0.000 0.023  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/21/1982    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Maleic hydrazide 
400         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1500         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
4000         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 70 0.700 46.0 37 0.370 31.0 6 0.060 5.0 27 0.270 19.0
Trend: 0.538 0.000 0.538  
Probability: 0.295 0.000 0.295  


Trial #:2   Activation: No Activation    Date: 01/13/1982    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Maleic hydrazide 
400         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1500         
 100 5 0.050 5.0 5 0.050 5.0 0 0.000 0.0 0 0.000 0.0 
3000         
 100 8 0.080 8.0 2 0.020 2.0 4 0.040 4.0 2 0.020 2.0 
4000         
 100 15 0.150 12.0 11 0.110 10.0 3 0.030 2.0 1 0.010 1.0
Positive Control: Mitomycin-C 
 0.25      
 100 19 0.190 16.0 12 0.120 11.0 6 0.060 6.0 1 0.010 1.0
Trend: 4.525 3.579 2.375  
Probability: 0.000 0.000 0.009  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 12/28/1981    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Maleic hydrazide 
50         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
160         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
500         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1600         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
5000         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 61 0.610 39.0 29 0.290 23.0 14 0.140 14.0 18 0.180 13.0
Trend: 0.886 0.000 0.886  
Probability: 0.188 0.000 0.188