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Study Information
Study Attribute Value
CEBS Accession Number: 002-02383-0005-0000-3
Chemical Name: Maleic hydrazide
CASRN: 123-33-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 869373_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/30/1980    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 429 0.409 8.58 26.0 0.000
Test Chemical Maleic hydrazide 
 0.1       
 50 1050 402 0.383 8.04 26.0 -6.383 
1         
 50 1049 455 0.434 9.10 26.0 6.061 
10         
 41 860 345 0.401 8.41 26.0 -1.907 
100         
 50 1047 474 0.453 9.48 26.0 10.701 
1000         
 50 1047 1933 1.846 38.66 26.0 351.443
Positive Control Triethylenemelamine 
 0.025     
 50 1047 2386 2.279 47.72 26.0 457.240
Trend: 35.281        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/30/1980    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 443 0.424 8.86 26.0 0.000
Test Chemical Maleic hydrazide 
 0.1       
 50 1045 457 0.437 9.14 26.0 3.259 
1         
 50 1050 428 0.408 8.56 26.0 -3.754 
10         
 50 1050 466 0.444 9.32 26.0 4.791 
100         
 50 1051 447 0.425 8.94 26.0 0.423 
1000         
 50 1048 456 0.435 9.12 26.0 2.738
Positive Control Cyclophosphamide 
1.5       
 50 1049 1788 1.704 35.76 26.0 302.457
Trend: 0.344        
Probability: 0.365