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Study Information
Study Attribute Value
CEBS Accession Number: 002-02385-0001-0000-1
Chemical Name: Malonaldehyde, sodium salt
CASRN: 24382-04-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 011163_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/18/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1042 393 0.377 7.86 26.5 0.000
Test Chemical Malonaldehyde, sodium salt 
14.9       
 50 1049 394 0.376 7.88 26.5 -0.415 
49.8       
 50 1044 479 0.459 9.58 26.5 21.649 
149         
 50 1041 596 0.573 11.92 26.5 51.800
Positive Control Mitomycin-C 
 0.002     
 50 1045 660 0.632 13.20 26.5 67.457
Mitomycin-C 
 0.01      
 10 208 331 1.591 33.10 26.5 321.929
Trend: 7.214        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/01/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1040 428 0.412 8.56 26.0 0.000
Test Chemical Malonaldehyde, sodium salt 
15         
 50 1048 529 0.505 10.58 26.0 22.655 
50         
 50 1036 568 0.548 11.36 26.0 33.223 
150         
 50 1045 726 0.695 14.52 26.0 68.815 
300         
 50 1038 1018 0.981 20.36 26.0 138.309
Positive Control Mitomycin-C 
 0.002     
 50 1036 496 0.479 9.92 26.0 16.335
Mitomycin-C 
 0.01      
 10 209 93 0.445 9.30 26.0 8.125
Trend: 16.577        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/18/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 453 0.433 9.06 26.0 0.000
Test Chemical Malonaldehyde, sodium salt 
149         
 50 1043 438 0.420 8.76 26.0 -2.940 
498         
 50 1047 533 0.509 10.66 26.0 17.660 
1490         
 50 1042 691 0.663 13.82 26.0 53.271
Positive Control Cyclophosphamide 
 0.5       
 50 1034 416 0.402 8.32 26.0 -7.013
Cyclophosphamide 
2.5       
 10 206 292 1.417 29.20 26.0 227.615
Trend: 7.885        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/01/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 470 0.449 9.40 26.0 0.000
Test Chemical Malonaldehyde, sodium salt 
150         
 50 1049 543 0.518 10.86 26.0 15.312 
500         
 50 1042 655 0.629 13.10 26.0 40.030 
1000         
 50 1039 613 0.590 12.26 26.0 31.430 
2000         
 50 1032 818 0.793 16.36 30.0 76.572
Positive Control Cyclophosphamide 
 0.5       
 100 2092 2049 0.979 20.49 26.0 118.187
Cyclophosphamide 
2.5       
 10 213 460 2.160 46.00 26.0 381.091
Trend: 9.943        
Probability: 0.000