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Study Information
Study Attribute Value
CEBS Accession Number: 002-02385-0002-0000-2
Chemical Name: Malonaldehyde, sodium salt
CASRN: 24382-04-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 011163_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 

Trial #:1   Activation: No Activation    Date: 10/01/1985    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 5 0.050 4.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Malonaldehyde, sodium salt 
42.9       
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0 
71.5       
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
143         
 100 5 0.050 5.0 1 0.010 1.0 3 0.030 3.0 1 0.010 1.0 
215         
 100 4 0.040 3.0 0 0.000 0.0 4 0.040 3.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 10 13 1.300 50.0 3 0.300 30.0 10 1.000 50.0 0 0.000 0.0
Mitomycin-C 
5         
 10 81 8.100 90.0 3 0.300 20.0 8 0.800 20.0 70 7.000 7.0
Trend: -0.140 -0.368 -0.524  
Probability: 0.556 0.644 0.700  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/09/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Malonaldehyde, sodium salt 
409         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
1640         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
3270         
 100 5 0.050 4.0 0 0.000 0.0 5 0.050 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 38 0.380 33.0 21 0.210 19.0 17 0.170 15.0 0 0.000 0.0
Trend: 0.590 -0.711 0.989  
Probability: 0.277 0.762 0.161  


Trial #:2   Activation: No Activation    Date: 08/09/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 8 0.080 7.0 0 0.000 0.0 6 0.060 6.0 2 0.020 2.0
Test Chemical: Malonaldehyde, sodium salt 
81.8       
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
245         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0 
409         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
5         
 100 69 0.690 46.0 24 0.240 20.0 45 0.450 35.0 0 0.000 0.0
Trend: -1.264 0.496 -1.201  
Probability: 0.897 0.310 0.885