Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02385-0009-0000-9
Chemical Name:	Malonaldehyde, sodium salt
CASRN:	24382-04-5
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	398708
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	78	65	128	55	51
			72	71	111	51
			67	164	97	48

Test Chemical	Malonaldehyde, sodium salt	125	89	148	189	71	79*
			58	126	159	92
			67	112	152	75
		250	95	100	178	62	67
			61	81	142	77
			82	85	153	62
		500					145*
			75	55	291	130
			51	63	245	161
		1000


Positive Control	Methyl Methane Sulfonate	5	55	48	974	587	596*
			58	63	831	478
			26	29	558	725

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	93	106	112	40	40
			94	97	108	38
			88	101	120	46
			83	96	87	35
Test Chemical	Malonaldehyde, sodium salt	300	82	69	167	68	66*
			79	76	152	64
			90	64	178	66
		400	68	71	222	109	102*
			83	61	243	98
			73	69	215	98
		500	89	53	320	120	108*
			83	52	237	95
			81	57	262	108
		600	77	63	232	100	101*
			72	37	243	112
			71	53	193	91
		800	58	32	374	216	210*
			65	41	338	175
			51	33	369	240
		1000	43	11	404	317	279*
			66	13	444	226
			54	10	478	295
Positive Control	Methyl Methane Sulfonate	5	49	28	678	463	405*
			39	23	521	443
			68	35	631	310

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination