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Study Information
Study Attribute Value
CEBS Accession Number: 002-02390-0001-0000-7
Chemical Name: Manganese sulfate monohydrate
CASRN: 10034-96-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 393357_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9   
Induced Rat Liver S9  2_S9  Positive 
Induced Rat Liver S9  3_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/28/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1036 421 0.406 8.42 25.5 0.000
Test Chemical Manganese sulfate monohydrate 
5         
 50 1036 536 0.517 10.72 25.5 27.316 
16.7       
 50 1024 657 0.642 13.14 34.0 57.886 
50         
 50 1026 686 0.669 13.72 34.0 64.534
Positive Control Mitomycin-C 
 0.001     
 50 1018 616 0.605 12.32 25.5 48.905
Mitomycin-C 
 0.01      
 5 104 250 2.404 50.00 25.5 491.540
Trend: 8.791        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/28/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 996 416 0.418 8.32 25.5 0.000
Test Chemical Manganese sulfate monohydrate 
167         
 50 1032 511 0.495 10.22 25.5 18.552 
500         
 0 0 0 0.000 0.00 0.0 N/A
Trend: 2.580        
Probability: 0.005        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/13/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1021 462 0.452 9.24 25.5 0.000
Test Chemical Manganese sulfate monohydrate 
200         
 50 1033 508 0.492 10.16 25.5 8.679 
245         
 50 1021 500 0.490 10.00 25.5 8.225 
298         
 12 239 133 0.556 11.08 25.5 22.981 
350         
 50 1012 683 0.675 13.66 25.5 49.150
Positive Control Cyclophosphamide 
15         
 25 512 559 1.092 22.36 25.5 141.282
Trend: 7.013        
Probability: 0.000        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 10/26/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1036 420 0.405 8.40 25.5 0.000
Test Chemical Manganese sulfate monohydrate 
300         
 50 1023 580 0.567 11.60 25.5 39.850 
332         
 50 1020 527 0.517 10.54 25.5 27.444 
350         
 50 1023 596 0.583 11.92 25.5 43.708
Positive Control Cyclophosphamide 
 0.3       
 50 1027 534 0.520 10.68 25.5 28.257
Cyclophosphamide 
2         
 5 104 122 1.173 24.40 25.5 189.359
Trend: 4.631        
Probability: 0.000