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Study Information
Study Attribute Value
CEBS Accession Number: 002-02390-0002-0000-8
Chemical Name: Manganese sulfate monohydrate
CASRN: 10034-96-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 393357_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 11/03/1982    Harvest Time: 19 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Water 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Manganese sulfate monohydrate 
150         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
176         
 100 6 0.060 6.0 2 0.020 2.0 2 0.020 2.0 2 0.020 2.0 
200         
 100 8 0.080 5.0 0 0.000 0.0 5 0.050 3.0 3 0.030 3.0
Positive Control: Mitomycin-C 
 0.062     
 50 11 0.220 18.0 6 0.120 12.0 5 0.100 3.0 0 0.000 0.0
Trend: 2.444 0.731 1.526  
Probability: 0.007 0.232 0.064  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/19/1982    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Water 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Manganese sulfate monohydrate 
400         
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0 
450         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0 
500         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
600         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 50 9 0.180 16.0 5 0.100 10.0 4 0.080 6.0 0 0.000 0.0
Trend: 1.512 1.263 1.263  
Probability: 0.065 0.103 0.103  


Trial #:2   Activation: No Activation    Date: 10/18/1982    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0
Water 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Manganese sulfate monohydrate 
141         
 100 7 0.070 3.0 0 0.000 0.0 4 0.040 2.0 3 0.030 3.0 
200         
 100 12 0.120 11.0 1 0.010 1.0 9 0.090 8.0 2 0.020 2.0 
300         
 100 8 0.080 8.0 2 0.020 2.0 2 0.020 2.0 4 0.040 4.0
Positive Control: Mitomycin-C 
 0.062     
 50 50 1.000 58.0 32 0.640 46.0 12 0.240 20.0 6 0.120 8.0
Trend: 2.730 0.905 1.486  
Probability: 0.003 0.183 0.069