COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02393-0001-0000-0
Chemical Name: Melamine
CASRN: 108-78-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 828756_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/26/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1027 569 0.554 11.38 25.5 0.000
Test Chemical Melamine 
150         
 50 1018 498 0.489 9.96 25.5 -11.704 
225         
 50 1033 704 0.682 14.08 25.5 23.007 
300         
 50 1027 727 0.708 14.54 25.5 27.768
Positive Control Mitomycin-C 
 0.005     
 25 517 928 1.795 37.12 25.5 223.978
Trend: 6.114        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/18/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 610 0.592 12.20 25.5 0.000
Test Chemical Melamine 
240         
 50 1013 618 0.610 12.36 25.5 3.112 
270         
 50 1013 623 0.615 12.46 25.5 3.946 
300         
 50 1025 698 0.681 13.96 25.5 15.096
Positive Control Mitomycin-C 
 0.005     
 25 516 649 1.258 25.96 25.5 112.581
Trend: 2.452        
Probability: 0.007        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/26/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 496 0.479 9.92 25.5 0.000
Test Chemical Melamine 
150         
 50 1036 501 0.484 10.02 25.5 1.008 
225         
 50 1027 454 0.442 9.08 25.5 -7.666 
300         
 50 1041 554 0.532 11.08 25.5 11.157
Positive Control Cyclophosphamide 
1.5       
 25 516 1011 1.959 40.44 25.5 309.241
Trend: 1.071        
Probability: 0.142