Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02393-0002-0000-1 |
Chemical Name: | Melamine |
CASRN: | 108-78-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 828756_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 |
Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | |
Test Chemical: | Melamine | 240 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
270 | 100 | 3 | 0.030 | 3.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
300 | 100 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.5 | 50 | 11 | 0.220 | 18.0 | 8 | 0.160 | 17.0 | 2 | 0.040 | 4.0 | 1 | 0.020 | 1.0 |
Trend: | 0.532 | 1.840 | -1.909 | ||||||||||||
Probability: | 0.297 | 0.033 | 0.972 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 |
Dimethyl Sulfoxide | 0 | 100 | 7 | 0.070 | 6.0 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | |
Test Chemical: | Melamine | 240 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
270 | 100 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
300 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | ||
Positive Control: | Cyclophosphamide | 25 | 50 | 11 | 0.220 | 20.0 | 9 | 0.180 | 18.0 | 1 | 0.020 | 2.0 | 1 | 0.020 | 1.0 |
Trend: | -0.963 | -0.165 | -1.909 | ||||||||||||
Probability: | 0.832 | 0.565 | 0.972 |